Epithelial genetic muscarinic receptor 3 ablation induces sex-specific modulation of colonic intestinal progenitor cells and response to intestinal injury

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Epithelial M3R ablation in mice leads to sex-dependent changes in colonic progenitor cell dynamics and epithelial homeostasis.
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Male mice with M3R knockout show reduced Lgr5-expressing progenitor cells, while females exhibit an expansion of these cells.
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M3R ablation results in severe inflammation in male mice during acute colitis, contrasting with minimal effects in female mice.
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Cholinergic and muscarinic signaling modulates colonic epithelial cells differently based on sex, indicating potential therapeutic targets.
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The study highlights the importance of considering sex-specific and regional differences in intestinal disorders and their treatment.

Journal Of Crohn's And Colitis

by Mohab Ragab, Jessica Wieland, Caroline Waldherr Avila de Melo, Tatiana Agibalova, Anastasia Ermolova, Niklas Durner, Anneke Hempel, Fabian Heindl, H Carlo Maurer, Katja Steiger, Klaus-Peter Janssen, Markus Tschurtschenthaler, Timothy C Wang, Michael Quante, Roland M Schmid, Moritz Middelhoff
March 7, 2025

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