-
1
MicroRNAs (miRNAs) are short, non-coding RNA molecules that regulate gene expression and play critical roles in cancer development.
-
2
Dysregulation of miRNAs can lead to various diseases, particularly cancers, acting as either oncogenes or tumor suppressors.
-
3
miRNA biogenesis involves a multi-tiered process including transcription, processing by Drosha and Dicer, and incorporation into the RISC complex.
-
4
Alterations in miRNA processing enzymes like Drosha and Dicer can disrupt miRNA levels, contributing to cancer progression.
-
5
miRNAs have significant potential as biomarkers for cancer diagnosis, prognosis, and targeted therapeutic approaches.
