Long-term outcomes of adjuvant proton radiotherapy (PRT) for residual pituitary adenoma (PA) in adults – a retrospective, single institute experience - Takeaways - MDSpire

Long-term outcomes of adjuvant proton radiotherapy (PRT) for residual pituitary adenoma (PA) in adults – a retrospective, single institute experience

  • By

  • Fabian J. K. Allmendinger

  • Maximilian Deng

  • Sebastian Regnery

  • Lars Wessel

  • Katharina Kozyra

  • Felix Englert

  • Ricarda Wickert

  • Jannik Walter

  • Lucas Mose

  • Thomas Tessonnier

  • Sandro M. Krieg

  • Jürgen Debus

  • Laila König

  • Tanja Adena-Eichkorn

  • June 12, 2026

  • 0 min

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  • 1

    Pituitary adenomas (PAs) can cause significant morbidity due to endocrine dysfunction and local mass effects.

  • 2

    Subtotal resection of PAs is common, with regrowth occurring in up to 60% of patients, necessitating additional treatment strategies.

  • 3

    Proton beam radiotherapy (PRT) offers advantages in sparing normal tissue compared to conventional radiotherapy for complex residual PAs.

  • 4

    This study reports on 22 adult patients receiving adjuvant PRT for residual PAs, highlighting the need for multidisciplinary decision-making.

  • 5

    Data collection included patient characteristics, tumor imaging, and follow-up reports to assess the long-term effects of PRT.

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