Genomic Characterization of Klebsiella pneumoniae Causing Invasive Disease in South African Infants: Observational Studies Between 2018 and 2023 - Takeaways - MDSpire

Genomic Characterization of Klebsiella pneumoniae Causing Invasive Disease in South African Infants: Observational Studies Between 2018 and 2023

  • By

  • Courtney P Olwagen

  • Alane Izu

  • Shama Khan

  • Stephanie Jones

  • Carmen Briner

  • Gaurav Kwatra

  • Lara Van der Merwe

  • Nicholas J Dean

  • Vicky L Baillie

  • Sana Mahtab

  • Kimberleigh Storath

  • Imaan Dunn

  • Lubomira Andrew

  • Urvi Rajyaguru

  • Firdose L Nakwa

  • Sithembiso C Velaphi

  • Jeannette Wadula

  • Renate Strehlau

  • Anika M van Niekerk

  • Niree Naidoo

  • Yogandree Ramsamy

  • Mohamed Said

  • Robert G K Donald

  • Raphael Simon

  • Ziyaad Dangor

  • Shabir A Madhi

  • January 20, 2026

  • 0 min

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  • 1

    Klebsiella pneumoniae is a major cause of invasive bacterial disease in infants in South Africa, with significant genotypic diversity identified.

  • 2

    A total of 337 KPn isolates were analyzed, revealing 85 distinct clonotypes, with ST17 being the most prevalent.

  • 3

    Eighty-five percent of KPn isolates exhibited multidrug resistance, with 32.9% resistant to carbapenems.

  • 4

    The study highlights the need for robust genomic surveillance to inform vaccine development against KPn in young African children.

  • 5

    The findings underscore the high burden of neonatal sepsis in low-middle-income countries, emphasizing the urgent need for effective interventions.

Original Source(s)

Genomic Characterization of Klebsiella pneumoniae Causing Invasive Disease in South African Infants: Observational Studies Between 2018 and 2023

  • by Courtney P Olwagen, Alane Izu, Shama Khan, Stephanie Jones, Carmen Briner, Gaurav Kwatra, Lara Van der Merwe, Nicholas J Dean, Vicky L Baillie, Sana Mahtab, Kimberleigh Storath, Imaan Dunn, Lubomira Andrew, Urvi Rajyaguru, Firdose L Nakwa, Sithembiso C Velaphi, Jeannette Wadula, Renate Strehlau, Anika M van Niekerk, Niree Naidoo, Yogandree Ramsamy, Mohamed Said, Robert G K Donald, Raphael Simon, Ziyaad Dangor, Shabir A Madhi

  • January 20, 2026

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