Development and internal validation of a nomogram for predicting short-term functional improvement after pharmacological treatment in severe symptomatic lumbar disk herniation - Takeaways - MDSpire

Development and internal validation of a nomogram for predicting short-term functional improvement after pharmacological treatment in severe symptomatic lumbar disk herniation

  • By

  • Hanze Mao

  • Guangqi Lu

  • Shuaiqi Zhou

  • Minghui Zhuang

  • Xin Xiu

  • Jing Li

  • Xinyue Sun

  • Yakun Liu

  • Mingming Ma

  • Jiaming Hu

  • Jie Yu

  • Liguo Zhu

  • June 8, 2026

  • 0 min

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  • 1

    A nomogram was developed to predict 14-day improvement in the Oswestry Disability Index for patients with severe lumbar disk herniation.

  • 2

    The study included 199 patients receiving pharmacological treatment, comparing Chinese patent medicine and NSAIDs.

  • 3

    Key predictors for ODI improvement included treatment group, sex, alkaline phosphatase levels, and degree of disk herniation.

  • 4

    Internal validation showed acceptable agreement between predicted and observed ODI improvements using bootstrap resampling.

  • 5

    The nomogram requires further validation before routine clinical use due to its preliminary nature and limited sample size.

Original Source(s)

Development and internal validation of a nomogram for predicting short-term functional improvement after pharmacological treatment in severe symptomatic lumbar disk herniation

  • by Hanze Mao, Guangqi Lu, Shuaiqi Zhou, Minghui Zhuang, Xin Xiu, Jing Li, Xinyue Sun, Yakun Liu, Mingming Ma, Jiaming Hu, Jie Yu, Liguo Zhu

  • June 8, 2026

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