A study of sex and age related heterogeneity in thyroid-gonadal axis interactions in a multi-center cohort of individuals with normal thyroid function - Takeaways - MDSpire

A study of sex and age related heterogeneity in thyroid-gonadal axis interactions in a multi-center cohort of individuals with normal thyroid function

  • By

  • Lina Yang

  • Haoran Hu

  • Qunhao Li

  • Jianjun Yang

  • Huxiao Liu

  • Mengya Chen

  • May 29, 2026

  • 0 min

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  • 1

    The study included 1,025 healthy participants with normal thyroid function to assess thyroid and sex hormone interactions.

  • 2

    FT4 showed a positive correlation with testosterone in men, while no significant association was found in the overall female population.

  • 3

    In females under 18, thyroid hormones negatively correlated with gonadotropins, while a positive correlation was observed in the 18-40 age group.

  • 4

    Multivariate analysis confirmed associations between FT4 and FSH, and TSH and LH in women of childbearing age.

  • 5

    The findings highlight significant gender differences and age-dependency in the relationship between thyroid and sex hormones.

Original Source(s)

A study of sex and age related heterogeneity in thyroid-gonadal axis interactions in a multi-center cohort of individuals with normal thyroid function

  • by Lina Yang, Haoran Hu, Qunhao Li, Jianjun Yang, Huxiao Liu, Mengya Chen

  • May 29, 2026

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