Distinct patterns of default mode network functional connectivity between adolescents with bipolar disorder and major depressive disorder - Takeaways - MDSpire

Distinct patterns of default mode network functional connectivity between adolescents with bipolar disorder and major depressive disorder

  • By

  • Yuxi Wang

  • Pengyu Zhu

  • Jialin Xiang

  • Junchen Gu

  • Xiong Chen

  • Fang Chen

  • Lulu Zou

  • Fuyi Qin

  • Dan Cheng

  • Dong Guan

  • Kun Qin

  • Chunqi Ai

  • Wen Chen

  • June 30, 2026

  • 0 min

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  • 1

    Adolescents with bipolar disorder (BD) show reduced functional connectivity (FC) in the default mode network (DMN) compared to healthy controls.

  • 2

    Patients with major depressive disorder (MDD) exhibit stronger FC in the DMN compared to BD patients, particularly between specific brain regions.

  • 3

    No significant differences in DMN connectivity were found between MDD patients and healthy controls, indicating distinct connectivity patterns.

  • 4

    Machine learning analysis yielded modest classification performance for distinguishing BD from MDD, with an area under the curve (AUC) of 0.609.

  • 5

    The study highlights the potential of DMN connectivity patterns as neurobiological markers for differentiating between BD and MDD in adolescents.

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