Distinct patterns of default mode network functional connectivity between adolescents with bipolar disorder and major depressive disorder

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Adolescents with bipolar disorder (BD) show reduced functional connectivity (FC) in the default mode network (DMN) compared to healthy controls.
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Patients with major depressive disorder (MDD) exhibit stronger FC in the DMN compared to BD patients, particularly between specific brain regions.
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No significant differences in DMN connectivity were found between MDD patients and healthy controls, indicating distinct connectivity patterns.
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Machine learning analysis yielded modest classification performance for distinguishing BD from MDD, with an area under the curve (AUC) of 0.609.
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The study highlights the potential of DMN connectivity patterns as neurobiological markers for differentiating between BD and MDD in adolescents.

Frontiers In Psychiatry

by Yuxi Wang, Pengyu Zhu, Jialin Xiang, Junchen Gu, Xiong Chen, Fang Chen, Lulu Zou, Fuyi Qin, Dan Cheng, Dong Guan, Kun Qin, Chunqi Ai, Wen Chen
June 30, 2026

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