PRP Linked to Better Outcomes in Advanced Knee OA - Takeaways - MDSpire
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PRP Linked to Better Outcomes in Advanced Knee OA

In a small open-label randomized trial, 2 platelet-rich plasma injections were associated with greater 6-month improvements in pain and function than corticosteroid injection or oral aceclofenac among patients awaiting knee arthroplasty.

  • By

  • Andrea Surnit

  • June 22, 2026

  • 6 min

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  • 1

    Two intra-articular platelet-rich plasma injections led to greater pain reduction and functional improvement over 6 months compared to corticosteroid or NSAID therapy.

  • 2

    The study involved 90 patients aged 40 to 80 years with advanced knee osteoarthritis awaiting knee replacement.

  • 3

    Pain scores improved significantly in the PRP group, with mean visual analogue scale scores declining from about 6 at baseline to about 3 at 3 months.

  • 4

    PRP was associated with lower levels of several serum biomarkers related to cartilage turnover and inflammation compared to corticosteroid and NSAID treatments.

  • 5

    The trial's design lacked a placebo group, limiting the conclusions about the efficacy of PRP compared to inert controls.

Original Source(s)

PRP Linked to Better Outcomes in Advanced Knee OA

  • by Andrea Surnit

  • June 22, 2026

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