Modelling fragile X-associated neuropsychiatric disorders in young inducible 90CGG premutation mice - Takeaways - MDSpire

Modelling fragile X-associated neuropsychiatric disorders in young inducible 90CGG premutation mice

  • By

  • Gürsel Çalışkan

  • Sara Enrile Lacalle

  • Emre Kul

  • Miguel del Ángel

  • Allison Loaiza Zambrano

  • Renate Hukema

  • Mónica Santos

  • Oliver Stork

  • June 2, 2025

  • 0 min

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  • 1

    The study utilized a 90CGG mouse model to investigate early neuropsychiatric symptoms associated with the FMR1 premutation.

  • 2

    Adolescent 90CGG mice exhibited hyperactivity, which transitioned to heightened anxiety in young adulthood, linked to intranuclear inclusions.

  • 3

    Electrophysiological analysis showed increased gamma oscillations in the ventral hippocampus, correlating with reduced parvalbumin interneurons.

  • 4

    Proteomic analysis revealed altered proteins associated with ADHD in adolescence and anxiety/depression in adulthood, aligning with behavioral findings.

  • 5

    Transgene inactivation reversed behavioral, electrophysiological, and cellular alterations, indicating potential therapeutic avenues for FXTAS.

Original Source(s)

Modelling fragile X-associated neuropsychiatric disorders in young inducible 90CGG premutation mice

  • by Gürsel Çalışkan, Sara Enrile Lacalle, Emre Kul, Miguel del Ángel, Allison Loaiza Zambrano, Renate Hukema, Mónica Santos, Oliver Stork

  • June 2, 2025

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