CKD Markers Linked to Cognitive Risk - Takeaways - MDSpire

CKD Markers Linked to Cognitive Risk

In adults with chronic kidney disease, higher proteinuria and lower estimated glomerular filtration rate are associated with increased risk of incident cognitive impairment.

  • By

  • Kathryn Wighton

  • February 17, 2026

  • 3 min

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  • 1

    A study found that reduced eGFR and high UPCR significantly increase the risk of cognitive impairment in CKD patients.

  • 2

    Each 1-standard deviation increase in UPCR correlates with a 21% higher likelihood of impaired attention and processing speed.

  • 3

    A 1-standard deviation decrease in eGFR is linked to a 21% increased likelihood of cognitive impairment, but this is less significant after adjusting for UPCR.

  • 4

    The CRIC Study followed 5,607 CKD adults, assessing cognitive outcomes with various standardized tests over multiple years.

  • 5

    Limitations of the study include potential misclassification of UPCR and exclusion of patients with end-stage kidney disease.

Original Source(s)

CKD Markers Linked to Cognitive Risk

  • by Kathryn Wighton

  • February 17, 2026

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