Clonal Candida auris candidemia outbreak in a tertiary care center with the first echinocandin-resistant isolates reported in Türkiye - Takeaways - MDSpire
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Outbreak of Clonal Candida auris Candidemia in a Tertiary Care Facility with the First Reported Echinocandin-Resistant Strains in Türkiye

  • By

  • Bram Spruijtenburg

  • Nevzat Unal

  • Carolina Melchior do Prado

  • Jacques F. Meis

  • Oğuzhan Bingöl

  • Tolga Toyran

  • Nida Akar

  • Nurettin Ay

  • Tuğba Arslan-Gülen

  • Tuba Turunç

  • Koray Daş

  • Ümit Çelik

  • Merve Kılıç-Çil

  • Macit Ilkit

  • Eelco F.J. Meijer

  • September 9, 2026

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  • 1

    A large Candida auris candidemia outbreak occurred at Adana City Hospital in Türkiye from April 2023 through September 2025.

  • 2

    The study identified 119 patients with C. auris candidemia; early cases were confined to burn center-associated wards and the medical oncology service before spreading more widely.

  • 3

    Two C. auris isolates had elevated echinocandin MICs and carried the FKS1 S639P substitution, representing the first reported echinocandin-resistant isolates in Türkiye.

  • 4

    All isolates were resistant to fluconazole, but the study did not report ERG11 mutations in these outbreak isolates; it noted that such mutations are common in clade I C. auris based on prior genomic studies.

  • 5

    The true burden of C. auris in Türkiye is likely underestimated because financial and structural limitations may hinder accurate and timely laboratory diagnosis.

Original Source(s)

Clonal Candida auris candidemia outbreak in a tertiary care center with the first echinocandin-resistant isolates reported in Türkiye

  • by Bram Spruijtenburg, Nevzat Unal, Carolina Melchior do Prado, Jacques F. Meis, Oğuzhan Bingöl, Tolga Toyran, Nida Akar, Nurettin Ay, Tuğba Arslan-Gülen, Tuba Turunç, Koray Daş, Ümit Çelik, Merve Kılıç-Çil, Macit Ilkit, Eelco F.J. Meijer

  • September 9, 2026

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