Multimodal treatment and long-term survival in a rare case of melanoma with pancreatic and splenic metastases: a case report and literature review - Takeaways - MDSpire

Multimodal treatment and long-term survival in a rare case of melanoma with pancreatic and splenic metastases: a case report and literature review

  • By

  • Yanhua Mou

  • Lan Han

  • Jing Yu

  • Hui Shen

  • Hui Li

  • Lichao Xu

  • Qingfeng Li

  • June 10, 2026

  • 0 min

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  • 1

    A 55-year-old man with metastatic melanoma developed rare pancreatic and splenic metastases following initial lower-extremity melanoma resection.

  • 2

    The patient underwent various treatment regimens, including toripalimab, anlotinib, and temozolomide, before transitioning to targeted therapy.

  • 3

    Surgical resection of the pancreatic and splenic metastases revealed a BRAF V600 mutation, allowing for targeted therapy with dabrafenib and trametinib.

  • 4

    As of March 6, 2025, the patient remains stable with long-term survival following a multimodal treatment approach.

  • 5

    The case emphasizes the importance of molecular monitoring and multidisciplinary collaboration in managing complex melanoma metastases.

Original Source(s)

Multimodal treatment and long-term survival in a rare case of melanoma with pancreatic and splenic metastases: a case report and literature review

  • by Yanhua Mou, Lan Han, Jing Yu, Hui Shen, Hui Li, Lichao Xu, Qingfeng Li

  • June 10, 2026

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