Case Report: Spatially fractionated radiation therapy for local recurrence after prior radiotherapy in advanced right-sided small cell lung cancer with mediastinal lymph node metastases - Takeaways - MDSpire

Case Report: Spatially fractionated radiation therapy for local recurrence after prior radiotherapy in advanced right-sided small cell lung cancer with mediastinal lymph node metastases

  • By

  • Tian Tian

  • Chunhua Dai

  • Xin Yang

  • Leyao Liu

  • Jicheng Zhang

  • Wuyang Yang

  • Tao You

  • May 11, 2026

  • 0 min

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  • 1

    A 63-year-old male with advanced right-sided small cell lung cancer experienced local recurrence in mediastinal lymph nodes after prior treatments.

  • 2

    The patient underwent Spatially Fractionated Radiation Therapy (SFRT) targeting mediastinal lymph nodes, achieving over 80% tumor regression.

  • 3

    SFRT was administered concurrently with atezolizumab immunotherapy, demonstrating significant relief of bronchial compression.

  • 4

    No significant radiation-related adverse events were reported during or after the SFRT treatment.

  • 5

    Long-term efficacy of SFRT in this case requires further observation and evaluation for future clinical management.

Original Source(s)

Case Report: Spatially fractionated radiation therapy for local recurrence after prior radiotherapy in advanced right-sided small cell lung cancer with mediastinal lymph node metastases

  • by Tian Tian, Chunhua Dai, Xin Yang, Leyao Liu, Jicheng Zhang, Wuyang Yang, Tao You

  • May 11, 2026

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