Single- vs Multiple-Dose Antibiotic Prophylaxis for Total Hip Arthroplasty - Takeaways - MDSpire
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Comparing Single and Multiple Doses of Antibiotics for Prophylaxis in Total Hip Arthroplasty

  • By

  • Armita Armina Abedi

  • Marie Anneberg

  • Alma Becic Pedersen

  • Claus Varnum

  • Robin Christensen

  • Søren Overgaard

  • September 18, 2026

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  • 1

    Periprosthetic joint infection (PJI) after total hip arthroplasty (THA) is serious, leading to repeat surgeries and higher healthcare costs.

  • 2

    Antibiotic prophylaxis is used to reduce PJI risk, but the optimal dosing regimen for primary THA remains debated and inconsistent.

  • 3

    This study utilized Danish registry data to compare the effectiveness of one preoperative antibiotic dose versus multiple doses for PJI prevention.

  • 4

    The primary outcome was PJI within 90 days post-THA, defined by specific culture and surgeon report criteria.

  • 5

    The study adhered to reporting guidelines and utilized validated data sources to enhance diagnostic accuracy for PJI.

Original Source(s)

Single- vs Multiple-Dose Antibiotic Prophylaxis for Total Hip Arthroplasty

  • by Armita Armina Abedi, Marie Anneberg, Alma Becic Pedersen, Claus Varnum, Robin Christensen, Søren Overgaard

  • September 18, 2026

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