Pasteurized Akkermansia muciniphila alleviates high-fat diet-induced bone loss via Nr4a1-dependent Treg differentiation - Takeaways - MDSpire

Pasteurized Akkermansia muciniphila alleviates high-fat diet-induced bone loss via Nr4a1-dependent Treg differentiation

  • By

  • Si Chen

  • Chenyang Zhang

  • Xue Liu

  • Yiying Zhu

  • Chenguang Niu

  • Wanqi Lv

  • May 22, 2026

  • 0 min

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  • 1

    Obesity disrupts bone metabolism through gut microbiota dysbiosis, making probiotic supplementation a potential intervention.

  • 2

    Pasteurized Akkermansia muciniphila (pAkk) significantly prevents high-fat diet-induced bone loss in obese mice.

  • 3

    pAkk enhances CD4+CD25+Foxp3+ Treg differentiation, which inhibits osteoclastogenesis and promotes bone formation.

  • 4

    The nuclear hormone receptor Nr4a1 is essential for pAkk-mediated Treg differentiation and its bone-protective effects.

  • 5

    This study identifies a novel gut microbiota-immune-bone axis linking Akkermansia muciniphila to bone homeostasis.

Original Source(s)

Pasteurized Akkermansia muciniphila alleviates high-fat diet-induced bone loss via Nr4a1-dependent Treg differentiation

  • by Si Chen, Chenyang Zhang, Xue Liu, Yiying Zhu, Chenguang Niu, Wanqi Lv

  • May 22, 2026

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