Interrelations of disease activity, health-related quality of life, and mental health in axial spondyloarthritis: the Rheuma-VOR cohort - Takeaways - MDSpire

Interrelations of disease activity, health-related quality of life, and mental health in axial spondyloarthritis: the Rheuma-VOR cohort

  • By

  • Lina Judit Schiestl

  • Eva Wendt

  • Fabian Proft

  • Kirsten Hoeper

  • Torsten Witte

  • Gunter Assmann

  • Andreas Schwarting

  • Matthias Dreher

  • May 13, 2026

  • 0 min

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  • 1

    Axial spondyloarthritis (axSpA) is characterized by inflammatory symptoms affecting the axial skeleton and significantly reduces health-related quality of life (HRQoL).

  • 2

    At diagnosis, 36.5% of axSpA patients exhibited depressive symptoms, and 69.5% reported significant fatigue, highlighting the mental health burden of the disease.

  • 3

    A one-year follow-up showed significant improvements in disease activity, functional impairment, HRQoL, mental health, and fatigue among axSpA patients.

  • 4

    Self-reported disease activity was a strong predictor of depressive symptoms and fatigue, while functional capacity was the best predictor of HRQoL.

  • 5

    Timely diagnosis and treatment initiation in axSpA are crucial for improving both physical and psychological outcomes, emphasizing the need for structured screening.

Original Source(s)

Interrelations of disease activity, health-related quality of life, and mental health in axial spondyloarthritis: the Rheuma-VOR cohort

  • by Lina Judit Schiestl, Eva Wendt, Fabian Proft, Kirsten Hoeper, Torsten Witte, Gunter Assmann, Andreas Schwarting, Matthias Dreher

  • May 13, 2026

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