Collision tumor of poorly differentiated thyroid carcinoma and intrathyroid thymic carcinoma arising in association with a branchial cleft-like cyst: a case report - Takeaways - MDSpire
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A Case Report of a Collision Tumor Featuring Poorly Differentiated Thyroid Carcinoma and Intrathyroid Thymic Carcinoma Associated with a Branchial Cleft-like Cyst

  • By

  • Sayed Ali Almahari

  • Jehad Hammad

  • Khalid Khan

  • Haneen Alboosta

  • Worood Husain

  • Jawaher Alansari

  • Yusuf Barhoom

  • August 12, 2026

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  • 1

    A collision tumor featuring poorly differentiated thyroid carcinoma (PDTC) and intrathyroid thymic carcinoma (ITTC) was reported in a 59-year-old male.

  • 2

    The patient initially presented with a benign branchial cleft cyst, which later progressed to a poorly differentiated carcinoma with squamous differentiation.

  • 3

    Histopathological analysis revealed distinct malignant components: PDTC and a squamous carcinoma associated with a benign cyst.

  • 4

    Immunohistochemical profiling supported the diagnosis, showing PDTC markers and squamous component positivity for CK5/6 and p63.

  • 5

    The patient succumbed to severe bronchopneumonia before further staging and treatment could be completed.

Original Source(s)

Collision tumor of poorly differentiated thyroid carcinoma and intrathyroid thymic carcinoma arising in association with a branchial cleft-like cyst: a case report

  • by Sayed Ali Almahari, Jehad Hammad, Khalid Khan, Haneen Alboosta, Worood Husain, Jawaher Alansari, Yusuf Barhoom

  • August 12, 2026

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