Association of triglyceride–glucose and obesity-derived indices with the risk of aortic stenosis among individuals in cardiovascular–kidney–metabolic syndrome stages 0–3: a prospective cohort study from the UK Biobank - Takeaways - MDSpire

Association of triglyceride–glucose and obesity-derived indices with the risk of aortic stenosis among individuals in cardiovascular–kidney–metabolic syndrome stages 0–3: a prospective cohort study from the UK Biobank

  • By

  • Jiacheng Ding

  • Xinyu Cai

  • Jingqian Li

  • Yiyin Gao

  • July 7, 2026

  • 0 min

Share

  • 1

    The study analyzed 363,907 UK Biobank participants with cardiovascular-kidney-metabolic syndrome stages 0-3.

  • 2

    Each 1-SD increment in triglyceride-glucose indices was linked to an 8-24% increased risk of aortic stenosis.

  • 3

    The highest tertile of triglyceride-glucose indices showed a 1.13-1.77-fold increased risk of aortic stenosis.

  • 4

    Systolic blood pressure mediated 12.1-18.1% of the associations between triglyceride-glucose indices and aortic stenosis.

  • 5

    TyG-WHtR demonstrated the greatest predictive improvement for aortic stenosis risk with a C-index of 0.806.

Original Source(s)

Association of triglyceride–glucose and obesity-derived indices with the risk of aortic stenosis among individuals in cardiovascular–kidney–metabolic syndrome stages 0–3: a prospective cohort study from the UK Biobank

  • by Jiacheng Ding, Xinyu Cai, Jingqian Li, Yiyin Gao

  • July 7, 2026

Related Content

Congenital heart defects genetic architecture in a small cohort: an integrated approach to prioritizing variants

Case Report: Non-bacterial thrombotic endocarditis and multiple thrombi uncover a hidden prothrombotic mutation

Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease