Diagnostic value of cystatin C in acute kidney injury among patients with sepsis: a systematic review and meta-analysis - Takeaways - MDSpire

Diagnostic value of cystatin C in acute kidney injury among patients with sepsis: a systematic review and meta-analysis

  • By

  • Luping Cheng

  • Bo Zhang

  • Xia Hu

  • Wenxin Wang

  • Hong Wan

  • Jun Liao

  • Chuanliang Pan

  • Deqiong Xie

  • June 10, 2026

  • 0 min

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  • 1

    This study evaluates cystatin C as a diagnostic marker for acute kidney injury in sepsis patients through a systematic review and meta-analysis.

  • 2

    Seventeen studies were included in the meta-analysis, revealing cystatin C's AUC of 0.88, sensitivity of 0.81, and specificity of 0.82 for diagnosing SA-AKI.

  • 3

    Subgroup analyses indicated that studies using Sepsis 3.0 criteria had higher specificity and diagnostic odds ratio, with reduced heterogeneity.

  • 4

    Combining cystatin C with other biomarkers improved diagnostic accuracy for sepsis-associated acute kidney injury.

  • 5

    The findings support cystatin C's potential as a valuable biomarker for early diagnosis of acute kidney injury in sepsis patients.

Original Source(s)

Diagnostic value of cystatin C in acute kidney injury among patients with sepsis: a systematic review and meta-analysis

  • by Luping Cheng, Bo Zhang, Xia Hu, Wenxin Wang, Hong Wan, Jun Liao, Chuanliang Pan, Deqiong Xie

  • June 10, 2026

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