Highly sensitized kidney transplant candidates: integrating acceptable mismatch, desensitization, imlifidase, and emerging immune-cell targeting strategies - Takeaways - MDSpire

Highly sensitized kidney transplant candidates: integrating acceptable mismatch, desensitization, imlifidase, and emerging immune-cell targeting strategies

  • By

  • Stefan Reuter

  • Nils Lachmann

  • Hans de Ferrante

  • Georg A. Böhmig

  • Klemens Budde

  • June 30, 2026

  • 0 min

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  • 1

    Highly sensitized kidney transplant candidates face challenges due to anti-HLA sensitization limiting access to compatible organs.

  • 2

    A compatibility-first access framework is proposed to enhance management and prioritize compatible transplantation options.

  • 3

    The Eurotransplant acceptable mismatch program combines expert-defined antigens with allocation priority for improved transplant outcomes.

  • 4

    Desensitization strategies, including imlifidase, are considered for candidates without realistic compatible options, especially in urgent cases.

  • 5

    Emerging immune-cell targeting strategies remain investigational but may enhance long-term feasibility for barrier-crossing transplantation.

Original Source(s)

Highly sensitized kidney transplant candidates: integrating acceptable mismatch, desensitization, imlifidase, and emerging immune-cell targeting strategies

  • by Stefan Reuter, Nils Lachmann, Hans de Ferrante, Georg A. Böhmig, Klemens Budde

  • June 30, 2026

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