CAR-T therapy utilizing Oncostatin-M ligand demonstrates significant anti-tumor efficacy in osteosarcoma treatment - Takeaways - MDSpire

CAR-T therapy utilizing Oncostatin-M ligand demonstrates significant anti-tumor efficacy in osteosarcoma treatment

  • By

  • Daniel Feinberg

  • Vinayak Uppin

  • Saada Eid

  • Claire Fritz

  • Masahiro Hitomi

  • Akshaya Radhakrishnan

  • Kayla Klatt

  • Sung Hee Choi

  • Jay T Myers

  • Aarshvi Bhatt

  • Duncan Stearns

  • Irina Pateva

  • Zachary D C Burke

  • Alex Y Huang

  • Gary K Schwartz

  • Reshmi Parameswaran

  • March 17, 2026

  • 0 min

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  • 1

    Osteosarcoma is the most common solid tumor in children, with a 5-year survival rate of 61-71%, but frontline therapies have not changed in over 30 years.

  • 2

    CAR-T therapy has shown limited efficacy against solid tumors like osteosarcoma, primarily due to tumor heterogeneity and differences in cytotoxic mechanisms.

  • 3

    Oncostatin M (OSM) receptors are highly expressed in osteosarcoma, making them promising targets for CAR-T cell therapy.

  • 4

    The study developed OSM ligand-based CAR-T cells that effectively kill osteosarcoma cells in vitro and in vivo, demonstrating significant anti-tumor efficacy.

  • 5

    OSM-CAR-T cells release IFNγ and specifically target osteosarcoma cells, suggesting potential for broader applications in solid tumors expressing OSM receptors.

Original Source(s)

CAR-T therapy utilizing Oncostatin-M ligand demonstrates significant anti-tumor efficacy in osteosarcoma treatment

  • by Daniel Feinberg, Vinayak Uppin, Saada Eid, Claire Fritz, Masahiro Hitomi, Akshaya Radhakrishnan, Kayla Klatt, Sung Hee Choi, Jay T Myers, Aarshvi Bhatt, Duncan Stearns, Irina Pateva, Zachary D C Burke, Alex Y Huang, Gary K Schwartz, Reshmi Parameswaran

  • March 17, 2026

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