Association between systemic inflammation response index and risk of major adverse cardiovascular events in adults with and without metabolic syndrome: a prospective cohort study in Shanghai, Pudong - Takeaways - MDSpire

Association between systemic inflammation response index and risk of major adverse cardiovascular events in adults with and without metabolic syndrome: a prospective cohort study in Shanghai, Pudong

  • By

  • Qiqi Meng

  • Juzhong Ke

  • Xiaonan Wang

  • Hua Qiu

  • Qingping Liu

  • Jiaojiao Gao

  • Jiahui Song

  • Yang Liu

  • Qian Xu

  • Mengyao Wu

  • Bo Huang

  • Yuling Qian

  • Lin Song

  • Xiaonan Ruan

  • Kang Wu

  • Yi Zhou

  • June 16, 2026

  • 0 min

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  • 1

    The study enrolled 3,198 participants from Pudong, Shanghai, with a median follow-up of 43 months to assess the link between SIRI and MACE.

  • 2

    Higher SIRI quartiles correlated with unfavorable metabolic profiles in participants, regardless of metabolic syndrome status.

  • 3

    Participants with metabolic syndrome in the highest SIRI quartile had a 2.33-fold increased risk of MACE compared to non-MS participants in the lowest quartile.

  • 4

    RCS analysis indicated a linear positive association between SIRI and MACE risk among participants with metabolic syndrome.

  • 5

    The study found a significant non-linear interaction between SIRI and fasting plasma glucose affecting cardiovascular risk.

Original Source(s)

Association between systemic inflammation response index and risk of major adverse cardiovascular events in adults with and without metabolic syndrome: a prospective cohort study in Shanghai, Pudong

  • by Qiqi Meng, Juzhong Ke, Xiaonan Wang, Hua Qiu, Qingping Liu, Jiaojiao Gao, Jiahui Song, Yang Liu, Qian Xu, Mengyao Wu, Bo Huang, Yuling Qian, Lin Song, Xiaonan Ruan, Kang Wu, Yi Zhou

  • June 16, 2026

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