Generation of functional canine TIL products for solid tumors

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Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) has shown effectiveness in human melanoma but faces challenges in low mutational burden tumors.
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Canine tumors provide a valuable model for studying TIL therapy due to their spontaneous occurrence in immunocompetent hosts and genetic similarities to human cancers.
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Protocols were developed to expand TILs from canine oral melanoma and appendicular osteosarcoma, demonstrating reactivity to autologous tumor cells.
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Canine oral melanoma and osteosarcoma have low tumor mutational burdens, making them suitable for evaluating TIL therapy's effectiveness in low-TMB conditions.
5

The study establishes the feasibility of generating functional canine TIL products, paving the way for comparative trials to enhance TIL responses in low-TMB malignancies.

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