A Comprehensive Review of Local Treatment Options for Hidradenitis Suppurativa: Current Strategies and Challenges - Takeaways - MDSpire

A Comprehensive Review of Local Treatment Options for Hidradenitis Suppurativa: Current Strategies and Challenges

  • By

  • Elisa Molinelli

  • Davide Febi

  • Edoardo De Simoni

  • Maria Luisa Dragonetti

  • Irene Richiardi

  • Matteo Candelora

  • Daisy Gambini

  • Sara Belleggia

  • Guendalina Lucarini

  • Oriana Simonetti

  • March 18, 2026

  • 0 min

Share

  • 1

    Local therapies are essential for managing mild hidradenitis suppurativa (HS) and serve as adjuncts in more severe cases.

  • 2

    Antiseptics and keratolytics are preferred over prolonged topical antibiotics to mitigate antimicrobial resistance.

  • 3

    Topical 15% resorcinol shows significant efficacy and may be a viable alternative to clindamycin for mild-to-moderate HS.

  • 4

    Intralesional corticosteroids and botulinum toxin can benefit selected patients, while topical JAK inhibitors need further validation.

  • 5

    Patient-reported outcome measures are crucial for assessing symptom relief from local therapies in HS management.

Original Source(s)

A Comprehensive Review of Local Treatment Options for Hidradenitis Suppurativa: Current Strategies and Challenges

  • by Elisa Molinelli, Davide Febi, Edoardo De Simoni, Maria Luisa Dragonetti, Irene Richiardi, Matteo Candelora, Daisy Gambini, Sara Belleggia, Guendalina Lucarini, Oriana Simonetti

  • March 18, 2026

Related Content

The Loan Cap That Could Shrink the Doctor Pipeline

New federal limits on medical school borrowing may quietly reshape who becomes a physician—and where they practice.

Dietary patterns, metabolic pathways and metainflammation in hidradenitis suppurativa: a systematic review

Meta-inflammation in Hidradenitis suppurativa: from pathogenic evidence to therapeutic approaches