New Insights From Perinatal HIV: A Way Forward for HIV Cure Research - Takeaways - MDSpire

New Insights From Perinatal HIV: A Way Forward for HIV Cure Research

  • By

  • Rajesh T Gandhi

  • Ronald J Bosch

  • Ann Chahroudi

  • January 30, 2026

  • 0 min

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  • 1

    Approximately 2.4 million children and adolescents are living with perinatal HIV, facing challenges in adhering to antiretroviral therapy.

  • 2

    Research indicates that early initiation of ART in children leads to lower levels of intact proviral DNA compared to late initiation.

  • 3

    Studies show a biphasic decline in intact proviruses in children, similar to patterns observed in adults undergoing ART.

  • 4

    Children receiving early ART may have smaller HIV reservoirs, potentially leading to longer times to viral rebound when ART is stopped.

  • 5

    Future research should focus on immune responses and factors affecting HIV reservoirs in children treated at different ages.

Original Source(s)

New Insights From Perinatal HIV: A Way Forward for HIV Cure Research

  • by Rajesh T Gandhi, Ronald J Bosch, Ann Chahroudi

  • January 30, 2026

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