Case report: Sequential complement inhibition and BAFF/APRIL blockade in progressive IgA nephropathy and IgA vasculitis nephritis: a report of two cases - Takeaways - MDSpire

Case report: Sequential complement inhibition and BAFF/APRIL blockade in progressive IgA nephropathy and IgA vasculitis nephritis: a report of two cases

  • By

  • Xinyuan Tian

  • Wanyin Hou

  • Xiaojuan Yu

  • Lei Jiang

  • Xin Zhang

  • Xu Zhang

  • Suxia Wang

  • Ying Tan

  • Lijun Liu

  • July 8, 2026

  • 0 min

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  • 1

    Rapidly progressive IgA nephropathy (IgAN) and IgA vasculitis nephritis (IgAVN) are associated with severe glomerular inflammation and rapid kidney function decline.

  • 2

    Two patients with aggressive IgAN and IgAVN received combined complement inhibition and BAFF/APRIL blockade, resulting in reduced proteinuria and stabilized kidney function.

  • 3

    The first patient, a 74-year-old woman, showed significant improvement in proteinuria and serum creatinine after treatment with eculizumab, iptacopan, and telitacicept.

  • 4

    The second patient, a 37-year-old man, also demonstrated nephrotic-range proteinuria and improved renal function following similar multi-pathway targeted therapy.

  • 5

    These cases suggest that multi-pathway targeted therapy may be a promising approach for selected patients with rapidly progressive IgAN or IgAVN.

Original Source(s)

Case report: Sequential complement inhibition and BAFF/APRIL blockade in progressive IgA nephropathy and IgA vasculitis nephritis: a report of two cases

  • by Xinyuan Tian, Wanyin Hou, Xiaojuan Yu, Lei Jiang, Xin Zhang, Xu Zhang, Suxia Wang, Ying Tan, Lijun Liu

  • July 8, 2026

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