Transcriptomics-based analysis of muscle injury mechanism mediated by inflammatory imbalance in the Duchenne muscular dystrophy muscle microenvironment - Takeaways - MDSpire
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Analysis of Muscle Injury Mechanisms in Duchenne Muscular Dystrophy: Insights from Transcriptomics and Inflammatory Imbalance in the Muscle Microenvironment

  • By

  • Chunhui Shan

  • Yu Li

  • Nan Li

  • Zhe Zhao

  • Yinhong Chen

  • Qi Bing

  • September 15, 2026

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  • 1

    Duchenne muscular dystrophy (DMD) is a hereditary neuromuscular disorder characterized by progressive myofiber damage and inflammation.

  • 2

    PTPRC was identified as a key gene associated with DMD and extracellular matrix (ECM) activation through transcriptomic analysis.

  • 3

    Patients with high PTPRC expression exhibited increased immune infiltration by M2 macrophages and regulatory T cells.

  • 4

    ECM activation scores were elevated in DMD patients and correlated with fibrosis, inflammatory pathway activation, and metabolic dysfunction.

  • 5

    Silencing PTPRC in myoblasts enhanced differentiation and reduced fibrotic characteristics, suggesting its role in DMD progression.

Original Source(s)

Transcriptomics-based analysis of muscle injury mechanism mediated by inflammatory imbalance in the Duchenne muscular dystrophy muscle microenvironment

  • by Chunhui Shan, Yu Li, Nan Li, Zhe Zhao, Yinhong Chen, Qi Bing

  • September 15, 2026

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