An Oxidative Glial Profile as a Predictor of Disability and Cognitive Decline in Primary Progressive Multiple Sclerosis - Takeaways - MDSpire

An Oxidative Glial Profile as a Predictor of Disability and Cognitive Decline in Primary Progressive Multiple Sclerosis

  • By

  • Albert Miguela

  • Joana Maria Huertas-Pons

  • Clàudia Coll-Martinez

  • Ariadna Gifreu-Fraixinó

  • Judit Salavedra-Pont

  • Manuel Comabella

  • Luisa María Villar

  • Jordi Gich

  • Gary Álvarez-Bravo

  • Lluís Ramió-Torrentà

  • Ana Quiroga-Varela

  • April 27, 2026

  • 0 min

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  • 1

    Primary progressive multiple sclerosis without inflammatory activity (PPMS-NA) is characterized by neurodegenerative processes and low systemic inflammation.

  • 2

    Elevated cerebrospinal fluid reactive oxygen species (CSF ROS) and interleukin-8 (IL-8) are potential biomarkers for predicting disability and cognitive decline in PPMS-NA.

  • 3

    Interleukin-6 (IL-6) shows time- and domain-specific effects on cognition, initially linked to attention and later inversely associated with memory.

  • 4

    CSF ROS correlates with brain atrophy, suggesting that oxidative stress plays a significant role in neurodegeneration in PPMS-NA.

  • 5

    Targeting oxidative stress and glial processes may offer therapeutic strategies for managing cognitive decline and disability in PPMS-NA.

Original Source(s)

An Oxidative Glial Profile as a Predictor of Disability and Cognitive Decline in Primary Progressive Multiple Sclerosis

  • by Albert Miguela, Joana Maria Huertas-Pons, Clàudia Coll-Martinez, Ariadna Gifreu-Fraixinó, Judit Salavedra-Pont, Manuel Comabella, Luisa María Villar, Jordi Gich, Gary Álvarez-Bravo, Lluís Ramió-Torrentà, Ana Quiroga-Varela

  • April 27, 2026

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