Impaired NLRP3 inflammasome activation by chitin underlies refractory chromoblastomycosis caused by Fonsecaea pedrosoi muriform cells - Takeaways - MDSpire

Impaired NLRP3 inflammasome activation by chitin underlies refractory chromoblastomycosis caused by Fonsecaea pedrosoi muriform cells

  • By

  • Yao Chen

  • Zilu Qu

  • Zhaolan Xie

  • Xiaowen Wang

  • Zhongsheng Tong

  • Luoyao Yang

  • Xu Zhang

  • Liuqing Chen

  • Bilin Dong

  • July 14, 2026

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  • 1

    Chitin accumulation on muriform cells of Fonsecaea pedrosoi impairs NLRP3 inflammasome activation, contributing to chronic chromoblastomycosis.

  • 2

    Human chromoblastomycosis lesions show significant neutrophil recruitment and multinucleated giant cells, indicating a complex immune response.

  • 3

    In wild type mice, lesions evolve from purulent to granulomatous over time, with a decline in pro-inflammatory cytokines.

  • 4

    NLRP3-deficient mice exhibit persistent IL-1β and IL-17A production, indicating an NLRP3-independent inflammatory response.

  • 5

    Chitinase-treated muriform cells induce higher NLRP3-dependent cytokine production in macrophages compared to intact muriform cells.

Original Source(s)

Impaired NLRP3 inflammasome activation by chitin underlies refractory chromoblastomycosis caused by Fonsecaea pedrosoi muriform cells

  • by Yao Chen, Zilu Qu, Zhaolan Xie, Xiaowen Wang, Zhongsheng Tong, Luoyao Yang, Xu Zhang, Liuqing Chen, Bilin Dong

  • July 14, 2026

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