Comparison of SOFA score alone versus SOFA score with interleukin-6 for outcome prediction in ICU patients with sepsis: a prospective observational study - Takeaways - MDSpire

Comparison of SOFA score alone versus SOFA score with interleukin-6 for outcome prediction in ICU patients with sepsis: a prospective observational study

  • By

  • Lalit Gupta

  • Anuradha Dialani

  • Shashank N. P.

  • Kapil Chaudhary

  • June 30, 2026

  • 0 min

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  • 1

    The study compared the prognostic accuracy of the SOFA score alone versus the combined SOFA score and interleukin-6 in ICU patients with sepsis.

  • 2

    Of the 40 enrolled patients, 60% survived and 40% died within 15 days, with non-survivors showing higher SOFA scores at admission.

  • 3

    IL-6 levels were consistently higher in non-survivors across Days 0 to 3, indicating its potential role in reflecting disease severity.

  • 4

    The combined SOFA-IL-6 score showed modest improvements in prognostic performance on Days 0 to 2 compared to SOFA alone.

  • 5

    On Day 3, both the combined score and SOFA alone demonstrated equivalent prognostic performance, with optimism-corrected AUCs of 0.908.

Original Source(s)

Comparison of SOFA score alone versus SOFA score with interleukin-6 for outcome prediction in ICU patients with sepsis: a prospective observational study

  • by Lalit Gupta, Anuradha Dialani, Shashank N. P., Kapil Chaudhary

  • June 30, 2026

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