The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling in Drosophila - Takeaways - MDSpire

The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling in Drosophila

  • By

  • Thiago C. Moulin

  • Michael J. Williams

  • Helgi B. Schiöth

  • May 20, 2026

  • 0 min

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  • 1

    Pan-neuronal knockdown of RasGAP1 in Drosophila leads to reduced locomotion and increased feeding, mimicking an obesity-like phenotype.

  • 2

    RasGAP1 knockdown results in elevated lipid storage and circulating sugars, alongside decreased expression of the leptin analog upd1.

  • 3

    Protein-interactome mapping reveals RasGAP1's role in linking Ras signaling with cytokine pathways that regulate feeding control.

  • 4

    Human analyses indicate that RASA2/3, KRAS, and LEP are associated with fat mass, BMI, and lipid dysregulation.

  • 5

    The study supports RasGAP1/RASA2/3 as a conserved neuro-metabolic regulator influencing obesity-related traits.

Original Source(s)

The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling in Drosophila

  • by Thiago C. Moulin, Michael J. Williams, Helgi B. Schiöth

  • May 20, 2026

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