Leukocyte activation and inflammation in acute myocardial infarction: novel insights from cell population data

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Immune dysregulation plays a significant role in acute myocardial infarction (AMI), contributing to inflammation and myocardial damage.
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Cell Population Data (CPD) analysis provides insights into leukocyte dynamics, including neutrophil and monocyte characteristics.
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Neutrophil and monocyte counts, along with neutrophil heterogeneity, are associated with cardiovascular mortality and inflammatory biomarkers.
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Lymphocyte count is inversely associated with cardiovascular death and inflammatory markers in patients with AMI.
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CPD parameters, particularly related to neutrophils and monocytes, may serve as predictive biomarkers for cardiovascular risk assessment.

Frontiers In Immunology

by Damien Leleu, Maxime Nguyen, Julien Guy, Michel Farnier, Frédéric Chagué, Laurine Collas, Margot Machado, Marine Gougeon, Jean-Paul Pais de Barros, Florence Bichat, Maud Maza, Yves Cottin, David Masson, Marianne Zeller
July 3, 2026

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