Oncological safety of portal vein embolization without prior tumour clearance in the future liver remnant followed by one-stage hepatectomy for bilateral colorectal liver metastases

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Upfront portal vein embolization (PVE) without prior tumor clearance can reduce the surgical burden of two-stage procedures for bilateral colorectal liver metastases.
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A study of 302 patients showed that PVE-OSH had a successful resection rate of 89%, compared to 79% for TSH-PVE and 96% for ALPPS.
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PVE-OSH patients experienced a median time of 6 weeks from intervention to major resection, shorter than the 9 weeks for TSH-PVE.
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Postoperative outcomes for liver failure, mortality, and overall survival were comparable across PVE-OSH, TSH-PVE, and ALPPS groups.
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Multivariable analysis identified the number of metastases and ALPPS as independent risk factors for liver recurrence.

Bjs (British Journal Of Surgery)

by Tim Reese, Dennis Björk, Anne M H Longva, Kristian S Kiim, Maximilian Evers, Peter N Larsen, Nicolai A Schultz, Bård I Røsok, Ulrik Carling, Fredrik Holmquist, Gert Lindell, Per Sandström, Jörg Böcker, Stefan Gilg, Jennie Engstrand, Christian Sturesson, Karl J Oldhafer, Bergthor Björnsson, Ernesto Sparrelid
September 22, 2025

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