Celiac disease as a model of gut–brain autoimmunity: from gluten exposure to neuropsychiatric manifestations - Takeaways - MDSpire

Celiac disease as a model of gut–brain autoimmunity: from gluten exposure to neuropsychiatric manifestations

  • By

  • Valentina Pucinischi

  • Martina Piersanti

  • Giovanni Di Nardo

  • Matteo Guarino

  • Umberto Volta

  • Roberto De Giorgio

  • Renata Auricchio

  • Alessandro Ferretti

  • Pasquale Parisi

  • Maurizio Mennini

  • May 14, 2026

  • 0 min

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  • 1

    Celiac disease (CeD) is an immune-mediated disorder triggered by gluten in genetically predisposed individuals.

  • 2

    CeD is associated with various neurological and psychiatric manifestations, including ataxia, depression, and ADHD.

  • 3

    Underlying mechanisms for neuropsychiatric symptoms in CeD may include autoimmune responses, gut dysbiosis, and neuroinflammation.

  • 4

    Clinical outcomes vary; some patients improve on a gluten-free diet, while others have persistent symptoms despite adherence.

  • 5

    Early identification and multidisciplinary management are crucial to prevent irreversible neurological damage in CeD patients.

Original Source(s)

Celiac disease as a model of gut–brain autoimmunity: from gluten exposure to neuropsychiatric manifestations

  • by Valentina Pucinischi, Martina Piersanti, Giovanni Di Nardo, Matteo Guarino, Umberto Volta, Roberto De Giorgio, Renata Auricchio, Alessandro Ferretti, Pasquale Parisi, Maurizio Mennini

  • May 14, 2026

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