Circulating microRNA molecular signatures converge with erythroid phenotypes and iron homeostasis in pediatric tic disorders

1

This study investigates the relationship between circulating microRNAs, erythroid characteristics, and iron regulation in children with tic disorders.
2

Children with tic disorders showed significant upregulation of hsa-miR-125b-5p and hsa-miR-23a-3p compared to healthy controls.
3

Erythroid parameters in tic disorder children indicated lower hemoglobin and serum ferritin levels, alongside altered mean corpuscular volume.
4

An integrated model combining specific microRNAs and erythroid indicators demonstrated excellent diagnostic performance for tic disorders.
5

The findings suggest a dysregulation of microRNAs and iron metabolism in tic disorders, potentially linking them to neurodevelopmental pathology.

Frontiers In Psychiatry

by Ru Jia, Tingting Zhu, Xue Tian, Simeng Wang, Si Zhang, Fei Fan, Yaru Wang, Yuxin Chai, Zilin Chen, Yuchen Hu, Weifeng Li, Fei Han
May 4, 2026

1