Weekly hippocampal diffusion changes during partial-brain radiation therapy for high-grade glioma: associations with dose and early memory change - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Weekly hippocampal diffusion changes during partial-brain radiotherapy for high-grade glioma: links to radiation dose and early memory outcomes

  • By

  • Ory Haisraely

  • Bikash Panthi

  • Kyle Richard Noll

  • Eleni Konstantinopoulou

  • Andrew Elliott

  • Sara Thrower

  • Holly Langshaw

  • Wasif Talpur

  • Catherine Sullaway

  • Todd Swanson

  • Chenyang Wang

  • Martin C. Tom

  • Thomas Beckham

  • Wen Jiang

  • Debra Nana Yeboa

  • Mary Frances McAleer

  • Amol Ghia

  • Susan Lynne McGovern

  • Jing Li

  • Jeffrey Scott Wefel

  • Caroline Chung

  • October 13, 2026

Share

  • 1

    This prospective, single-arm observational analysis included 45 adults with high-grade glioma treated with 60 Gy in 30 fractions over 6 weeks.

  • 2

    Bilateral hippocampal ADC and FA were measured before radiotherapy and weekly during treatment using diffusion MRI.

  • 3

    The study assessed associations between planned mean hippocampal dose and weekly diffusion trajectories during partial-brain radiotherapy.

  • 4

    Exploratory analyses examined whether baseline-to-Week 6 diffusion changes were associated with early memory change measured by the Cogstate C3 battery.

  • 5

    ADC and FA were treated as nonspecific imaging phenotypes of early tissue response, not direct or validated indicators of irreversible radiation injury.

Original Source(s)

Weekly hippocampal diffusion changes during partial-brain radiation therapy for high-grade glioma: associations with dose and early memory change

  • by Ory Haisraely, Bikash Panthi, Kyle Richard Noll, Eleni Konstantinopoulou, Andrew Elliott, Sara Thrower, Holly Langshaw, Wasif Talpur, Catherine Sullaway, Todd Swanson, Chenyang Wang, Martin C. Tom, Thomas Beckham, Wen Jiang, Debra Nana Yeboa, Mary Frances McAleer, Amol Ghia, Susan Lynne McGovern, Jing Li, Jeffrey Scott Wefel, Caroline Chung

  • October 13, 2026

Related Content

Defensive responses to the U.S. Surgeon General’s alcohol-cancer advisory: A topic modeling analysis of TikTok comments

Screening strategies for the early detection of non-cardia gastric cancer in low- to moderate-prevalence regions: Asia-Pacific gastroesophageal cancer congress consensus 2026

Overall survival of Black patients with newly diagnosed multiple myeloma in the era of triplet and quadruplet therapies