Intercellular mitochondrial transfer in melanoma progression and therapeutic resistance: mechanisms and targeting potential

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Intercellular mitochondrial transfer facilitates metabolic communication, enabling melanoma cells to exchange functional mitochondria and enhance survival.
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Melanoma's progression and treatment resistance are linked to mitochondrial reprogramming, allowing cells to restore oxidative phosphorylation under stress.
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Mitochondrial transfer can promote therapeutic resistance, immune evasion, and increased metastatic potential in melanoma cells.
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In certain contexts, mitochondrial transfer may have tumor-suppressive effects by enhancing immune cell metabolism and activating immune pathways.
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Understanding mitochondrial transfer mechanisms may lead to novel therapeutic strategies for precision treatment in melanoma.

Frontiers In Oncology

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