Female-specific hypertension risk factors across the lifecourse: a co-twin control analysis using the California Twin Program - Takeaways - MDSpire

Female-specific hypertension risk factors across the lifecourse: a co-twin control analysis using the California Twin Program

  • By

  • Kellie R Imm

  • Wendy Cozen

  • Kim Siegmund

  • Amie E Hwang

  • Myles Cockburn

  • Ann Hamilton

  • Thomas Mack

  • Victoria Kristence Cortessis

  • January 13, 2026

  • 0 min

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  • 1

    The study utilized a discordant co-twin design to investigate hypertension risk factors unique to women throughout their lifecourse.

  • 2

    Overweight at age 18 and adulthood significantly increased the odds of hypertension, with a 3-fold and 6-fold increase respectively.

  • 3

    Higher levels of exercise were associated with lower odds of hypertension, with exercising more than one's co-twin linked to reduced risk.

  • 4

    Menopause was positively correlated with hypertension, showing a 4-fold increase in odds for postmenopausal twins compared to premenopausal twins.

  • 5

    The study confirmed multiple female-specific hypertension risk factors, emphasizing the need for targeted interventions in women's health.

Original Source(s)

Female-specific hypertension risk factors across the lifecourse: a co-twin control analysis using the California Twin Program

  • by Kellie R Imm, Wendy Cozen, Kim Siegmund, Amie E Hwang, Myles Cockburn, Ann Hamilton, Thomas Mack, Victoria Kristence Cortessis

  • January 13, 2026

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