High-dose accelerated intermittent theta burst stimulation targeting the primary motor cortex for gait and cognitive functions in cerebral small vessel disease: a randomized controlled trial - Takeaways - MDSpire

High-dose accelerated intermittent theta burst stimulation targeting the primary motor cortex for gait and cognitive functions in cerebral small vessel disease: a randomized controlled trial

  • By

  • Xiao-Ying Zhao

  • Jia-Jing Tian

  • Bei-Yan Guan

  • Hua-Wei Chen

  • Shi-Yao Wang

  • Xin-Yang Zhang

  • Yan-Wei Miao

  • Chun-Li Song

  • Bing-Wei Zhang

  • June 1, 2026

  • 0 min

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  • 1

    High-dose accelerated intermittent theta burst stimulation (aiTBS) was tested for treating gait and cognitive dysfunction in patients with cerebral small vessel disease (CSVD).

  • 2

    The study involved 36 patients, randomly assigned to receive either real aiTBS or sham treatment over 14 sessions, assessing various clinical outcomes.

  • 3

    Real aiTBS significantly improved multidimensional gait and cognitive assessments compared to sham treatment, with notable effects on 3mTUG and Tinetti scores.

  • 4

    At the 4-week follow-up, improvements in cognitive function were observed, although no significant differences were found in the MoCA scores between groups.

  • 5

    The therapeutic response to aiTBS correlated with neuroimaging features of CSVD, indicating its potential as a valuable treatment for gait and cognitive disorders.

Original Source(s)

High-dose accelerated intermittent theta burst stimulation targeting the primary motor cortex for gait and cognitive functions in cerebral small vessel disease: a randomized controlled trial

  • by Xiao-Ying Zhao, Jia-Jing Tian, Bei-Yan Guan, Hua-Wei Chen, Shi-Yao Wang, Xin-Yang Zhang, Yan-Wei Miao, Chun-Li Song, Bing-Wei Zhang

  • June 1, 2026

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