CT-Based Radiogenomic Prediction of ICAM1 and RAET1E as Biomarkers of NK Cytotoxicity in Clear Cell Renal Cell Carcinoma - Takeaways - MDSpire

CT-Based Radiogenomic Prediction of ICAM1 and RAET1E as Biomarkers of NK Cytotoxicity in Clear Cell Renal Cell Carcinoma

  • By

  • Ma, Xinwei

  • Yang, Jiao

  • Qian, Xusheng

  • Dou, Xin

  • Ji, Shiliang

  • Dai, Yakang

  • Yang, Yi

  • Wang, Yi

  • Zhu, Jianbing

  • May 20, 2026

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  • 1

    This study develops a noninvasive CT-based radiogenomic framework to assess NK cell cytotoxicity biomarkers in clear cell renal cell carcinoma.

  • 2

    Preoperative contrast-enhanced CT images from 143 ccRCC patients and transcriptomic data from 538 TCGA-KIRC samples were analyzed.

  • 3

    ICAM1 and RAET1E were identified as key biomarkers, with AUC values of 75.7% and 67.3%, respectively, indicating strong radiogenomic associations.

  • 4

    Higher ICAM1 and lower RAET1E expression correlated with advanced tumor stage and poorer survival outcomes in ccRCC patients.

  • 5

    The study supports the feasibility of using CT-derived radiomic features for noninvasive immune characterization in ccRCC.

Original Source(s)

CT-Based Radiogenomic Prediction of ICAM1 and RAET1E as Biomarkers of NK Cytotoxicity in Clear Cell Renal Cell Carcinoma

  • by Ma, Xinwei , Yang, Jiao , Qian, Xusheng , Dou, Xin , Ji, Shiliang , Dai, Yakang , Yang, Yi , Wang, Yi , Zhu, Jianbing

  • May 20, 2026

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