Neuropathologic basis of quantitative susceptibility mapping in the substantia nigra: contributions of tau, pigmented neurons, and iron - Takeaways - MDSpire

Neuropathologic basis of quantitative susceptibility mapping in the substantia nigra: contributions of tau, pigmented neurons, and iron

  • By

  • Daisuke Ono

  • Sravya Kondrakunta

  • Elijah Mak

  • Scott A. Przybelski

  • Angela J. Fought

  • Christopher G. Schwarz

  • Melissa E. Murray

  • Aivi Nguyen

  • Ross R. Reichard

  • Matthew L. Senjem

  • Jeffrey L. Gunter

  • Clifford R. Jack

  • Toji Miyagawa

  • Leah K. Forsberg

  • Julie A. Fields

  • Rodolfo Savica

  • Vijay K. Ramanan

  • David T. Jones

  • Hugo Botha

  • Erik K. St. Louis

  • David S. Knopman

  • Neill R. Graff-Radford

  • Gregory S. Day

  • Tanis J. Ferman

  • Walter K. Kremers

  • Val J. Lowe

  • Ronald C. Petersen

  • Bradley F. Boeve

  • Dennis W. Dickson

  • Kejal Kantarci

  • February 18, 2026

  • 0 min

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  • 1

    Quantitative susceptibility mapping (QSM) measures magnetic susceptibility in brain tissue, influenced by iron accumulation and neuroinflammation.

  • 2

    Elevated QSM values in the substantia nigra are associated with Lewy body disease, including Parkinson's disease and dementia with Lewy bodies.

  • 3

    Tau burden and glial cell density contribute to tissue magnetic susceptibility in the substantia nigra, complicating QSM interpretation.

  • 4

    The study included 59 participants who underwent MRI and autopsy to evaluate neuropathologic measures and their correlation with QSM values.

  • 5

    Digital pathology and machine learning were utilized to quantify histologic parameters in the substantia nigra across various neurodegenerative diseases.

Original Source(s)

Neuropathologic basis of quantitative susceptibility mapping in the substantia nigra: contributions of tau, pigmented neurons, and iron

  • by Daisuke Ono, Sravya Kondrakunta, Elijah Mak, Scott A. Przybelski, Angela J. Fought, Christopher G. Schwarz, Melissa E. Murray, Aivi Nguyen, Ross R. Reichard, Matthew L. Senjem, Jeffrey L. Gunter, Clifford R. Jack, Toji Miyagawa, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Vijay K. Ramanan, David T. Jones, Hugo Botha, Erik K. St. Louis, David S. Knopman, Neill R. Graff-Radford, Gregory S. Day, Tanis J. Ferman, Walter K. Kremers, Val J. Lowe, Ronald C. Petersen, Bradley F. Boeve, Dennis W. Dickson, Kejal Kantarci

  • February 18, 2026

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