Integrative single-cell and bulk transcriptomic analyses identify DRAM1 as a candidate gene from fibroblast-associated transcriptional programs in colorectal cancer - Takeaways - MDSpire

Integrative single-cell and bulk transcriptomic analyses identify DRAM1 as a candidate gene from fibroblast-associated transcriptional programs in colorectal cancer

  • By

  • Rudong Li

  • Zhipeng Zhao

  • Hengyu Liu

  • Chao Zhang

  • Zhicheng Wang

  • Siyi Wang

  • Xudong Wang

  • June 11, 2026

  • 0 min

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  • 1

    Colorectal cancer (CRC) exhibits significant cellular heterogeneity and complex interactions within the tumor microenvironment.

  • 2

    Fibroblasts play a crucial role in CRC progression through diverse transcriptional programs and intercellular communications.

  • 3

    The study identified DRAM1 as a candidate gene linked to fibroblast-related transcriptional networks in CRC.

  • 4

    Experimental validation showed that silencing DRAM1 increased CRC cell proliferation, migration, and invasion.

  • 5

    DRAM1 may function as a tumor-restraining factor in CRC, warranting further investigation into its role in stromal-immune regulation.

Original Source(s)

Integrative single-cell and bulk transcriptomic analyses identify DRAM1 as a candidate gene from fibroblast-associated transcriptional programs in colorectal cancer

  • by Rudong Li, Zhipeng Zhao, Hengyu Liu, Chao Zhang, Zhicheng Wang, Siyi Wang, Xudong Wang

  • June 11, 2026

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