Developmental neurotoxicity of atrazine: decreased synaptic spine density and miRNA-driven GluN2A downregulation in primary hippocampal neurons - Takeaways - MDSpire

Developmental neurotoxicity of atrazine: decreased synaptic spine density and miRNA-driven GluN2A downregulation in primary hippocampal neurons

  • By

  • Melania Maria Serafini

  • Agnese Graziosi

  • Miriam Midali

  • Luca Ghelli

  • Giacomo Grumelli

  • Giulia Sita

  • Emanuela Corsini

  • Marina Marinovich

  • Fabiana Morroni

  • Barbara Viviani

  • July 14, 2026

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  • 1

    Atrazine (ATZ) is a widely used herbicide, banned in Europe since 2004, but still extensively applied in other countries, including the US.

  • 2

    ATZ exposure can occur through contaminated water and food, with potential occupational exposure during manufacturing and application.

  • 3

    In vivo studies indicate that ATZ can cross the blood-brain and placental barriers, affecting fetal brain development.

  • 4

    Chronic ATZ exposure has been associated with alterations in NMDA glutamatergic gene expression in the hippocampus.

  • 5

    The study aims to investigate how ATZ affects synaptic spine development and glutamatergic receptor expression in primary hippocampal neurons.

Original Source(s)

Developmental neurotoxicity of atrazine: decreased synaptic spine density and miRNA-driven GluN2A downregulation in primary hippocampal neurons

  • by Melania Maria Serafini, Agnese Graziosi, Miriam Midali, Luca Ghelli, Giacomo Grumelli, Giulia Sita, Emanuela Corsini, Marina Marinovich, Fabiana Morroni, Barbara Viviani

  • July 14, 2026

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