Cortical morphological alterations in methamphetamine-induced psychosis: a surface-based morphometry study - Takeaways - MDSpire

Cortical morphological alterations in methamphetamine-induced psychosis: a surface-based morphometry study

  • By

  • Danlin Shen

  • Dan Luo

  • Mingfeng Lai

  • Hongge Tao

  • Jiajun Xu

  • Jing Li

  • November 17, 2025

  • 0 min

Share

  • 1

    Methamphetamine use affects approximately 7.4 million people globally and is linked to severe health issues, including psychosis and increased mortality.

  • 2

    Methamphetamine-induced psychosis (MAP) has a prevalence rate of 43% among individuals with Methamphetamine Use Disorder (MUD), leading to significant negative outcomes.

  • 3

    Neuroimaging studies reveal structural brain abnormalities in chronic METH users, particularly in the orbitofrontal cortex, striatum, and limbic systems.

  • 4

    The study aims to identify distinct cortical patterns of neurostructural abnormalities in MAP and MUD patients, and their relationship with craving intensity.

  • 5

    Participants included MUD patients and healthy controls, with diagnoses confirmed using the DSM-5 criteria and assessments conducted via MRI and clinical interviews.

Original Source(s)

Cortical morphological alterations in methamphetamine-induced psychosis: a surface-based morphometry study

  • by Danlin Shen, Dan Luo, Mingfeng Lai, Hongge Tao, Jiajun Xu, Jing Li

  • November 17, 2025

Related Content

Romanian male patients with the dual diagnosis of schizophrenia and alcohol use disorder: a prospective study of clinical, social, and treatment-related factors affecting quality of life

An idiographic network approach to modeling daily loneliness and paranoia in psychosis: implications for personalized interventions

The many manifestations of magical thinking: a systematic review