Mitochondrial DNA Variation, Antiretroviral Therapy, and Incidence of Diabetes Among Men With and Without HIV - Takeaways - MDSpire
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Influence of Mitochondrial DNA Variability and Antiretroviral Treatment on Diabetes Risk in Men With and Without HIV

  • By

  • Craig Cronin

  • Todd T Brown

  • Hsing-Yu Hsu

  • David C Samuels

  • Weiqun Tong

  • Sudipa Sarkar

  • Alison G Abraham

  • Jeremy J Martinson

  • Shehnaz K Hussain

  • Steven Wolinsky

  • Todd Hulgan

  • Jing Sun

  • January 3, 2026

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  • 1

    Mitochondrial dysfunction is linked to higher diabetes mellitus prevalence in people with HIV compared to those without.

  • 2

    African mtDNA haplogroup L3 significantly increases the risk of developing diabetes in men with HIV.

  • 3

    Exposure to mitochondrial-toxic antiretroviral therapy, particularly D-drugs, is independently associated with increased diabetes risk.

  • 4

    The study analyzed 2598 men, including 1349 with HIV, to assess the relationship between mtDNA and diabetes incidence.

  • 5

    Understanding mitochondrial genetics may help address diabetes risk in the aging population of people living with HIV.

Original Source(s)

Mitochondrial DNA Variation, Antiretroviral Therapy, and Incidence of Diabetes Among Men With and Without HIV

  • by Craig Cronin, Todd T Brown, Hsing-Yu Hsu, David C Samuels, Weiqun Tong, Sudipa Sarkar, Alison G Abraham, Jeremy J Martinson, Shehnaz K Hussain, Steven Wolinsky, Todd Hulgan, Jing Sun

  • January 3, 2026

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