Application Value of Resting-State fMRI in Preoperative Lateralization of Language Areas in Epilepsy with Left-Sided Epileptogenic Foci

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The study analyzed language lateralization in 36 epilepsy patients with left-sided foci compared to 45 healthy controls.
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Non-classical language dominance was found to be higher in epilepsy patients (69.4%) than in controls (45.5%).
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Wernicke's area showed a higher rate of non-classical dominance (81.8%) compared to Broca's area (50.0%).
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The laterality index–activation map consistency was 83.3%, indicating reliable preoperative language lateralization assessment.
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The left Broca's area retained core language function, while the left Wernicke's area showed significant functional impairment.

Frontiers In Neurology

by Wang, Zihao , Hu, Tian-Qi , Meng, Wang , Li, Ying , Sun, Yaning , Zhang, Di , Li, Wen-Ling
May 29, 2026

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