Determinants of Brain Metastasis Development and Survival in Breast Cancer Patients: Insights from a Multi-Center Study

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Breast cancer is the most diagnosed cancer in women, with an increasing incidence and decreasing mortality rates due to improved therapies.
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Brain metastasis occurs in 20%-40% of breast cancer patients, significantly impacting survival outcomes, especially in triple negative cases.
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Treatment options for brain metastasis from breast cancer include surgery, radiotherapy, and systemic chemotherapy, with multimodal approaches showing promise.
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The Breast-GPA tool incorporates key variables to predict survival in breast cancer patients with brain metastasis, aiding treatment decisions.
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A study of 318 patients revealed demographic and treatment patterns, highlighting the need for tailored approaches in managing brain metastasis.

Bmc Cancer

by Ahmad Alhalabi, Theresa Abdo, Ali Hijazi, Mohamed Mohanna, Rami Tfayli, María Herrán, Saad Sabbagh, Saffet Guleryuz, Razan Mohanna, Rashid Mahrous, Kaylee Sarna, Surabhi Ranjan, Christopher W Fleming, Zeina Nahleh
December 19, 2025

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