Sex Differences in Leptin Levels in Children and Adolescents with Normal Weight and Overweight/Obesity Across Pubertal Stages: A Systematic Review and Meta-analysis - Takeaways - MDSpire

Sex Differences in Leptin Levels in Children and Adolescents with Normal Weight and Overweight/Obesity Across Pubertal Stages: A Systematic Review and Meta-analysis

  • By

  • Rutuja Dhamale

  • Alejandra V Rodríguez Rondón

  • Eline E P L van der Walle

  • Erica L T van den Akker

  • Jenny A Visser

  • November 15, 2025

  • 0 min

Share

  • 1

    Leptin levels differ significantly between normal-weight boys and girls throughout puberty, with girls exhibiting higher levels.

  • 2

    In children with overweight or obesity, sex differences in leptin levels observed in normal-weight children are diminished.

  • 3

    At the postpubertal stage, girls with overweight or obesity have significantly higher leptin levels compared to boys.

  • 4

    Boys with overweight or obesity have a higher body mass index SD score than girls during puberty.

  • 5

    Leptin's role in puberty initiation may be influenced by other factors, such as kisspeptin, particularly in the context of obesity.

Original Source(s)

Sex Differences in Leptin Levels in Children and Adolescents with Normal Weight and Overweight/Obesity Across Pubertal Stages: A Systematic Review and Meta-analysis

  • by Rutuja Dhamale, Alejandra V Rodríguez Rondón, Eline E P L van der Walle, Erica L T van den Akker, Jenny A Visser

  • November 15, 2025

Related Content

High prevalence of thyroid nodules and their association with cardiometabolic risk in Mongolia

American horses are obese, too

Tirzepatide for Recurrent Weight Gain after Bariatric Procedures: Real-World Evidence of Efficacy and Safety