EQUIPOISE: EQUivalence In Prostate cancer treatment: surgery Or radiotherapy? An Intention-to-treat Survival analysis from real-world Evidence - Takeaways - MDSpire
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EQUIPOISE: Real-World Intention-to-Treat Survival Analysis Comparing Surgery and Radiotherapy for Prostate Cancer

  • By

  • Gustavo A. Viani

  • Ana Carolina Hamamura

  • Caio Viani Arruda

  • Carlos E. Cardoso

  • Helio A. Salmon

  • Gustavo O. Amaral

  • October 15, 2026

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  • 1

    This retrospective study compared intention-to-treat survival after surgery or radiotherapy plus androgen deprivation in men with intermediate- or high-risk localized prostate cancer in São Paulo.

  • 2

    The cohort included 21,292 men diagnosed from 2014 through 2023: 15,735 initially received surgery and 5,557 received radiotherapy plus androgen deprivation.

  • 3

    Before matching, radiotherapy recipients were older and had more high-risk disease and greater comorbidity-related treatment differences than surgery recipients.

  • 4

    The primary outcome was cancer-specific survival, with other-cause mortality treated as a competing event; overall survival was the secondary outcome.

  • 5

    In the surgery group, 20.2% received at least one additional treatment modality after prostatectomy.

Original Source(s)

EQUIPOISE: EQUivalence In Prostate cancer treatment: surgery Or radiotherapy? An Intention-to-treat Survival analysis from real-world Evidence

  • by Gustavo A. Viani, Ana Carolina Hamamura, Caio Viani Arruda, Carlos E. Cardoso, Helio A. Salmon, Gustavo O. Amaral

  • October 15, 2026

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