Risk factors for conversion to mastectomy due to positive margins in early breast cancer patients when choosing breast-conserving surgery: a retrospective cohort study - Takeaways - MDSpire

Risk factors for conversion to mastectomy due to positive margins in early breast cancer patients when choosing breast-conserving surgery: a retrospective cohort study

  • By

  • Ning-chen Wang

  • Xing Zhang

  • Yuan-yuan Xu

  • June 11, 2026

  • 0 min

Share

  • 1

    This study analyzed risk factors for conversion to mastectomy due to positive margins in early breast cancer patients undergoing breast-conserving surgery.

  • 2

    Among 290 patients, significant factors associated with conversion to mastectomy included low BMI, multifocality, larger tumor size, and DCIS component.

  • 3

    Multivariable logistic regression identified low BMI (OR 4.611), multifocality (OR 4.863), larger tumor size (OR 3.197), and DCIS (OR 5.308) as robust predictors.

  • 4

    The study emphasizes the importance of identifying these risk factors preoperatively to improve surgical planning and patient outcomes.

  • 5

    Breast-conserving surgery aims for complete tumor removal while preserving breast appearance, but positive margins can lead to increased re-excision rates.

Original Source(s)

Risk factors for conversion to mastectomy due to positive margins in early breast cancer patients when choosing breast-conserving surgery: a retrospective cohort study

  • by Ning-chen Wang, Xing Zhang, Yuan-yuan Xu

  • June 11, 2026

Related Content

Adjuvant chemotherapy combined with pembrolizumab immunotherapy for primary triple-negative neuroendocrine carcinoma of the breast: a case report and literature review

A prediction model and risk stratification tool for survival by chemotherapy in invasive micropapillary carcinoma of the breast: a population-based study with external validation

POC1A promotes malignant phenotypes in non-triple-negative breast cancer cell models with EMT- and Wnt/β-catenin-related alterations